【作者】Liping Lu ，Xiaoli Gao ，Miaoli Zhu ，Sulian Wang ，Qiong Wu ，Shu Xing ，Xueqi Fu ，Zhiwei Liu ，Maolin Guo
【刊名】Biometals
【作者单位】1. Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Shanxi University, Taiyuan, 030006, Shanxi, People’s Republic of China 4. Department of Chemistry, Taiyuan Normal University, Taiyuan, 030001, People’s Republic of China 2. Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun, 130023, People’s Republic of China 3. UMass Cranberry Health Research Center, Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, Dartmouth, MA, 02747, USA
【年份】2012
【卷号】Vol.25 No.3
【页码】599-610
【ISSN】0966-0844
【关键词】Biguanido-oxovanadium complexes Protein tyrosine phosphatases Competitive inhibition Selective inhibition
【摘要】 The inhibitory effects of three biguanido–oxovanadium complexes ([VO(L 1−3 ) 2 ]·nH 2 O: HL 1 = metformin, HL 2 = phenformin, HL 3 = moroxydine) against four protein tyrosine phosphatases (PTPs) and an alkaline phosphatase (ALP) were investigated....
