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Natural fulvic acids inhibit non-small-cell lung cancer through the COX-2/PGE2/EP4 axis: In silico and in vivo assessments

  • 【获取途径】 OA资源
  • 【作者】Pengfei Xin,Shirui Wang,Xin Xu,Qingmei Liu,Caifeng Zhang
  • 【刊名】Heliyon
  • 【作者单位】1Department of Stomatology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China;2Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China;3Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China;4Department of Chemistry, Taiyuan Normal University, Humic Acid Engineering and Technology Research Center of Shanxi Province, Jinzhong, 030619, China
  • 【年份】2023
  • 【卷号】Vol.9 No.6
  • 【页码】e17080
  • 【ISSN】2405-8440
  • 【关键词】Fulvic acids Humic acids Non-small-cell lung cancer Molecular docking COX-2 EP4 
  • 【摘要】 Purpose Non-small-cell lung cancer is a major public health concern with a high incidence worldwide. Coal-derived fulvic acids contain functional groups in their chemical structures. Overexpression of cyclooxygenases-2 , prostaglandin E2 , and the ...
  • 【文献类型】 期刊
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