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Probing the interaction between the metallo-β-lactamase SMB-1 and ampicillin by multispectral approaches combined with molecular dynamics

  • 【作者】Jiachen Li, Xiaoting Dong, Yeli Zhang
  • 【刊名】Journal of molecular recognition : JMR
  • 【作者单位】Affiliations 1 College of Biological Sciences and Technology, Taiyuan Normal University, Jinzhong, China. 2 Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.
  • 【年份】2024
  • 【页码】e3100
  • 【ISSN】1099-1352
  • 【关键词】SMB‐1 from Serratia marcescents ampicillin fluorescence spectra molecular dynamic molecular recognition. 
  • 【摘要】 Metallo-β-lactamases hydrolyze and inactivate β-lactam antibiotics, are a pivotal mechanism conferring resistance against bacterial infections. SMB-1, a novel B3 subclass of MβLs from Serratia marcescens could deactivate almost all β-lactam antibiot...
  • 【文献类型】 期刊
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