One-Pot Regioselective Synthesis of Spiroimidazolidinones via a Sequential Ugi 4CR/Azide-Isocyanide Coupling/Cyclization/Rearrangement/Hydroxylation Reaction
【作者】Yan-Mei Yan，Hong-Bo Tong，Zhen-Xing Ren，Hong-Li Zhang，Jiao Wang，Ying-Chun He，Yong-Zhao Wang
【刊名】Organic Letters
【作者单位】1College of Chemistry and Materials, Taiyuan Normal University, Jinzhong 030619, P. R. of China;2Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, P. R. of China;3Engineering Research Center of Ministry of Education for Fine Chemicals, Shanxi University, Taiyuan 030006, P. R. of China
【年份】2025
【卷号】Vol.27 No.5
【页码】1216-1220
【ISSN】1523-7060
【摘要】 Herein a novel and robust methodology to spiroimidazolidinones has been developed under a mild reaction. The reaction of -2-azido-3-phenylacrylic acids 1 , aldehydes 2 , amines 3 , isocyanides 4 , and isocyanides 6 produced regioselectively spiroimid...
