Fluoride induces apoptosis and alters collagen I expression in rat osteoblasts

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【作者】Yan X，Yan X，Morrison A，Li J，Wang J.
【刊名】Toxicology Letters
【作者单位】Shanxi Key Laboratory of Ecological Animal Science and Environmental Medicine, Shanxi Agricultural University, Taigu, Shanxi 030801, PR China; Department of Biology, Taiyuan Normal University, Taiyuan, Shanxi 030012, PR China; Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo-SUNY, Buffalo, NY 14214, USA.
【年份】2010
【ISSN】0378-4274
【关键词】Animals Animals, Newborn Apoptosis/*drug effects Cell Cycle/drug effects Cell Survival/drug effects Cells, Cultured Collagen/biosynthesis/genetics Collagen Type I/*biosynthesis/genetics Female Fluorescent Antibody Technique Immunohistochemistry Osteoblasts/*drug effects/*metabolism/ultrastructure Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Sodium Fluoride/*toxicity
【摘要】 In this study we investigated apoptosis and expression of the collagen I gene in newborn rat osteoblasts (OB) by the administration of varying concentrations of fluoride (F). Sodium fluoride (NaF) at concentrations of 0, 0.5, 5, 10, and 20mg/L was ad...
【文献类型】期刊