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Development and validation of a rapid capillary zone electrophoresis method for determining charge variants of mAb

  • 【作者】Shi, Y ,Li, Z ,Qiao, YB ,Lin, J
  • 【刊名】Journal of Chromatography B
  • 【作者单位】[ 1 ] Taiyuan Normal Univ, Dept Biol, Taiyuan 030031, Shanxi, Peoples R China   增强组织信息的名称     Taiyuan Normal University        [ 2 ] Luliang Univ, Grad Inst Pharmaceut Chem, Luliang 033000, Shanxi, Peoples R China        [ 3 ] Interbio Co Ltd, Analyt Sci, Shanghai 201203, Peoples R China
  • 【年份】2012
  • 【卷号】Vol.906
  • 【页码】63-68
  • 【ISSN】1570-0232
  • 【关键词】Capillary zone electrophoresis Therapeutic monoclonal antibody Optimization Validation Application 
  • 【摘要】 This work aimed to develop a rapid capillary zone electrophoresis (CZE) method to provide abundant purity and identity information of monoclonal antibodies. The CZE running buffer system was optimized to be 20 mM acetate–acetic acid (pH 6.0) together...
  • 【文献类型】 期刊
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