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Development and validation of a rapid capillary zone electrophoresis method for determining charge variants of mAb

  • 【作者】Shi, Y.,Li, Z.,Qiao, Y.,Lin, J.
  • 【刊名】Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
  • 【作者单位】a Department of Biology, Taiyuan Normal University, 030031 Shanxi, China; b Graduate Institute of Pharmaceutical Chemistry, Luliang University, 033000 Shanxi, China; c Analytical Sciences, Interbio Co. Ltd., 201203 Shanghai, China
  • 【年份】2012
  • 【卷号】Vol.906
  • 【页码】63-68
  • 【ISSN】1570-0232
  • 【关键词】Application Capillary zone electrophoresis Optimization Therapeutic monoclonal antibody Validation 
  • 【摘要】 This work aimed to develop a rapid capillary zone electrophoresis method to provide abundant purity and identity information of monoclonal antibodies. The CZE running buffer system was optimized to be 20. mM acetate-acetic acid together with the co...
  • 【文献类型】 期刊
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