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Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis

  • 【作者】Shuhua Shan,Jiangying Shi,Peng Yang,Bin Jia,Haili Wu,Xiaoli Zhang,Zhuoyu Li
  • 【刊名】Journal of Agricultural and Food Chemistry
  • 【作者单位】Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Institute of Biotechnology, Shanxi University , Taiyuan 030006, China School of Life Science and Technology, Shanxi University , Taiyuan 030006, China § Department of Biology, Taiyuan Normal University , Taiyuan 030619, China School of Basic Medical Science, Shanxi Medical University , Taiyuan 030006, China
  • 【年份】2017
  • 【卷号】Vol.65 No.37
  • 【页码】8136-8144
  • 【ISSN】0021-8561
  • 【关键词】apigenin cell proliferation colon cancer cells glycolysis pyruvate kinase M2 
  • 【摘要】 Apigenin (AP), as an anticancer agent, has been widely explored. However, the molecular targets of apigenin on tumor metabolism are unclear. Herein, we found that AP could block cellular glycolysis through restraining the tumor-specific pyruvate kina...
  • 【文献类型】 期刊
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