Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis

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【作者】Shan, Shuhua，Shi, Jiangying，Yang, Peng
【刊名】JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
【作者单位】a Key Laboratory of Chemical Biology and Molecular Engineering, National Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, 030006, China; b School of Life Science and Technology, Shanxi University, Taiyuan, 030006, China; c Department of Biology, Taiyuan Normal University, Taiyuan, 030619, China; d School of Basic Medical Science, Shanxi Medical University, Taiyuan, 030006, China
【年份】2017
【卷号】Vol.65 No.37
【页码】8136-8144
【ISSN】0021-8561;1520-5118
【关键词】apigenin cell proliferation colon cancer cells glycolysis pyruvate kinase M2
【摘要】 Apigenin , as an anticancer agent, has been widely explored. However, the molecular targets of apigenin on tumor metabolism are unclear. Herein, we found that AP could block cellular glycolysis through restraining the tumor-specific pyruvate kinase M...
【文献类型】期刊