Design, preparation and characterization of octopus-like self-releasing intracellular protein transporter LEB5 based on Escherichia coli heat-labile enterotoxin
【作者】Di Liu，Yafen Zhan，Xiaoying Wu，Hongping Qiao，Yeli Zhang，Bo Li
【刊名】International journal of biological macromolecules
【作者单位】Affiliations 1 College of Biological Sciences and Technology and Center for Veterinary Medicine, Taiyuan Normal University, Jinzhong 030619, Shanxi, China. Electronic address: diliu@tynu.edu.cn. 2 College of Biological Sciences and Technology and Center for Veterinary Medicine, Taiyuan Normal University, Jinzhong 030619, Shanxi, China. 3 College of Biological Sciences and Technology and Center for Veterinary Medicine, Taiyuan Normal University, Jinzhong 030619, Shanxi, China; School of Environmental Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, Shanxi, China. Electronic address: libo01@tyut.edu.cn.
【年份】2023
【页码】124172
【ISSN】1879-0003
【关键词】Endoplasmic reticulum targeting Heat-labile enterotoxin Intracellular protein transporter Intracellular self-releasing.
【摘要】 Despite the great potential of protein drugs as intracellular therapeutic agents, the unmet challenge in breaking through the cell membrane barrier and delivering them to intracellular targets remains. Therefore, developing safe and effective deliver...
